K. Thirupathaiah
Department of Chemistry, M.V.S. Government Arts & Science College, Mahabubnagar, 509001, T.G, India.
G. Satyanarayana Goud
Department of Chemistry, M.V.S. Government Arts & Science College, Mahabubnagar, 509001, T.G, India.
M. Mallesh
Department of Chemistry, M.V.S. Government Arts & Science College, Mahabubnagar, 509001, T.G, India.
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http://doi.org/10.37648/ijrst.v14i02.010
A Convenient method for the synthesis of novel imidazole-2-thiones containing allomaltol and isoxazole fragments was presented. This synthesis involves a one-pot multicomponent reaction of allomaltol, arylglyoxals, isoxazole amines followed by in situ addition of alkyl or aryl isothiocyanates. The reaction produces initially the key intermediate viz., ?-amino ketones and imidazoline -2-thiones which were not isolated. The advantages of this protocol involves mild reaction conditions, atom economy and easy work-up procedure, without intervention of tedious chromatographic process.
Keywords: One-pot synthesis; imidazole-2-thiones with allomaltol and isoxazole fragments; easy work- up; good yield.
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