Development of Substituted 4-Methyl-5-nitro-2-(1-phenyl-1H-[1, 2, 3] Triazol-4-yl Methoxy) Pyridine Derivatives via Synthetic Approaches and its Characterization
G. Satyanarayana Goud
Assistant Professor, Department of Chemistry, Dr. BRR Government Degree College, Jadcherla, Telangana
Lavanya Rumandla
Department of Chemistry, N T R Government Degree College, Mahabubnagar, Telangana - 509001
62-71
Vol: 10, Issue: 3, 2020
Receiving Date:
2026-07-14
Acceptance Date:
2026-08-22
Publication Date:
2026-09-18
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http://doi.org/10.37648/ijrst.v10i03.009
Abstract
The 1,2,3-triazole ring is one of the most significant nitrogen-containing five-membered heterocyclic motifs due to its broad applicability in medicinal chemistry, chemical biology, organic synthesis, supramolecular chemistry, and industrial applications [1-2]. Numerous clinically important pharmaceuticals contain a 1,2,3-triazole core, highlighting its significance in medicinal chemistry. Notable examples include the anticonvulsant drug Rufinamide, the broad-spectrum cephalosporin antibiotic Cefatrizine, the anticancer agent Carboxyamidotriazole, and the ?-lactamase inhibitor Tazobactam, among others [3].The triazole ring system is present in a number of physiologically active natural compounds as well as pharmaceuticals [4], and it possesses capabilities that are anti-inflammatory [5], antimicrobial [6], anticancer [7], and antiviral [8]. In recent years, a great number of combinatorial approaches have been published [9]. Studies on the cycloaddition of different azides with various alkynes [10] have proliferated over the course of the past several decades, with a focus on “regio-control on terminal substrates in the Cu-catalysed vs uncatalyzed reaction”.
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