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Stereoselective Total Synthesis of an Anti-Fouling Agent, C2-Symmetricnatural Macrolide Trichobotryside A

K. Nagi Reddy

Department of Chemistry, Mahatma Gandhi University, Nalgonda, Telangana - 508 254, INDIA

Mandala Jyothi

Department of Chemistry, KRR Government Arts and Science College (A), Kodad, Suryapet, Telangana, INDIA

23-32

Vol: 16, Issue: 1, 2026

Receiving Date: 2025-11-19 Acceptance Date:

2025-12-31

Publication Date:

2026-01-17

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http://doi.org/10.37648/ijrst.v16i01.003

Abstract

A stereoselective total synthesis of 16-membered macrodiolide trichobotryside A has been successfully completed. The key features are: Evans’ Crotylation, regioselective epoxide opening, Wardsworth-Emmons-Horner Olefination and Mitsunobu Reaction.

Keywords: Macrodiolide; anti-fouling agent; Evans’ Crotylation; Super Hydride; regioselective epoxide opening; Wardsworth-Emmons-Horner Olefination; Mitsunobu Reaction

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