Ishika Yadav
Shiv Nadar School, Gurgaon
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http://doi.org/10.37648/ijrst.v14i04.007
A steady loss in cellular and physiological processes is a hallmark of ageing, a complicated biological condition that increases susceptibility to illness and mortality. Numerous interrelated biological processes, such as telomere attrition, genomic instability, epigenetic changes, mitochondrial dysfunction, cellular senescence, loss of proteostasis, and others, are responsible for this process. These processes cause tissue deterioration, disturb cellular homeostasis, and foster inflammation, which pave the way for age-related illnesses like cancer, heart disease, neurological disorders, and metabolic syndromes. Even while our understanding of these systems has advanced significantly, it must be improved to translate fundamental research into effective treatment plans. The cellular causes of ageing are thoroughly examined in this work, along with how they contribute to age-related illnesses and new therapeutic strategies such as telomerase activation, mitochondrial therapies, senolytics, and epigenetic reprogramming. This work attempts to promote a better knowledge of ageing and direct the development of therapies to enhance health span and postpone the start of age-associated illnesses by combining cellular biology, molecular genetics, and innovative therapeutics.
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