info@ijrst.com

+919555269393

Track Article

Upload Article

IJRST
About
About IJRST Editorial Board Reviewers Advisory Board Call for Papers Subject Areas Indexing
For Author
Peer Review Guidelines Instruction for Authors Submission Process Manuscript Withdrawal Article Processing Charge Invitation for Reviewers Review Process Article Workflow
Policies
Open Access Policy Review Policy Publication Ethics Article Correction Policy Plagiarism Policy Conflict of Interest Policy
Archive
Past Issues Current Issue
Download
Paper Template Copyright Form Cover Page AIU Prospectus
Certificate FAQ Contact Upload Article Track Article

Details

The Protective Potential of Metformin against Liver Acetaminophen Toxicity

Dina Suhail

PhD in Al-Yarmouk University College, Department of Pharmacy, Iraq

1-6

Vol: 11, Issue: 3, 2021

Receiving Date: 2021-05-29 Acceptance Date:

2021-07-07

Publication Date:

2021-07-17

Download PDF

http://doi.org/10.37648/ijrst.v11i03.001

Abstract

The inadequacy to replace acetaminophen (APAP) with a more effective analgesic continues its use in therapeutic interventions, upholding the risk of hepatotoxicity. Depletion of glutathione reserves by a metabolic intermediate of acetaminophen, N-acetyl-p-benzoquinone imine (NAPQI), is the major reason. The current study presents the combinatorial effect of metformin, a biguanide, in ameliorating the APAP toxicity. HepG2 cells were used for in vitro studies and MTT and LDH leakage assays were used for viability assessment. 10 μM of metformin improved the cell viability and membrane integrity of cells treated with a high antioxidant enzymes and reduced glutathione were significantly increased in cells co-administrated with metformin and acetaminophen

Keywords: metformin; acetaminophen toxicity; liver toxicity; HepG2 cells; necrosis

References

  1. Anon. 2010. Tylenol professional product information. Fort Washington (MD): McNeil Consumer Healthcare, Division of McNEIL-PPC, IncBajt ML, Knight TR, Farhood A, Jaeschke H. Scavenging peroxynitrite with glutathione promotes regeneration and enhances survival during acetaminophen-induced liver injury in mice. J PharmacolExpTher. 307:67–73, 2003
  2. R. Dart, A. Erdman, K. Olson, G. Christianson and A. Manoguerra. 2006. Acetaminophen poisoning: an evidence based consensus guideline for out-of-hospital management. ClinToxicol (Phila). 44:1–18, 2006
  3. N. Kaplowitz, M. Shinohara, Z. Liu, and D. Han. How to protect against acetaminophen: don't ask for JUNK. Gastroenterology. 135:1047–1051, 2008.
  4. M. McGill, C. Williams, M. Taha, S. Curry and H. Jaeschke. The mechanism underlying acetaminophen induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. J Clin Invest. 122:1574–1583, 2012
  5. M. Poon, P. Chiu, D. Mak and K. Ko. Metformin protects against carbon tetrachloride hepatotoxicity in mice. J Pharmacol Sci. 93:501–504, 2003.
  6. A. Reid, R. Kurten, S. McCullough, R. Brock and J. Hinson. Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes. J PharmacolExpTher. 312:509–516, 2005
  7. M. Tavafi. Complexity of diabetic nephropathy pathogenesis and design of investigations. J Renal Inj Prev. 2:59–62, 2013a
  8. M. Tavafi. Diabetic nephropathy and antioxidants. J Nephropathol. 2:20–27, 2013b
  9. S. Saravi, A. Hasanvand, K. Shahkarami and A. Dehpour. The protective potential of metformin against acetaminophen induced hepatotoxicity in BALB/C mice, Pharmaceutical Biology, vol54:pp12, 2830-2837, 2016.
  10. M. Yana, Y. Huob, S. Yina and H. Hu. Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions. Redox Biology 17, 274–283, 2018.
  11. G. Rena, D. Hardie and E. Pearson. The mechanisms of action of metformin. Diabetologia. vol 60, pp 9 :1577-1585, 2017 Sep.
Back

Disclaimer: All papers published in IJRST will be indexed on Google Search Engine as per their policy.

We are one of the best in the field of watches and we take care of the needs of our customers and produce replica watches of very good quality as per their demands.

Our Head Office

Aryavart International University
Mission Tilla, Dharmanagar, North Tripura, India

+91-9555269393

info@ijrst.com

Quick Links

Plagiarism Policy Current Issue Certificate Reviewers FAQs Our Journals

Indexing

© IJRST, All Right Reserved.

Designed By Krrypto