Immunohistochemical Expression of CDX2 and its Correlation with Clinicopathological Parameters in Colorectal Neoplasms
Niranjana Chellappa,
Dept of Pathology, Sri Ramachandra Medical Centre & Research Institute, Chennai
Sandhya Sundaram
Dept of Pathology, Sri Ramachandra Medical Centre & Research Institute, Chennai
Lawrence D Cruze
Dept of Pathology, Sri Ramachandra Medical Centre & Research Institute, Chennai
Vishwanath Pai
Dept of Surgery, Sri Ramachandra Medical Centre & Research Institute, Chennai
Simon C Durairaj
Dept of Pathology, Sri Ramachandra Medical Centre & Research Institute, Chennai
34-40
Vol: 7, Issue: 1, 2017
Receiving Date:
2016-11-02
Acceptance Date:
2016-12-27
Publication Date:
2017-01-24
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Abstract
Colorectal Carcinoma is one of the most commonly diagnosed cancers worldwide. They are known to be preceded by metaplasia and adenomas. Screening, early diagnosis and intervention have found to improve the prognosis substantially. Therefore there is a vital need to identify and stratify colonic cancers according to the degree of aggressiveness. CDX2 is a master regulator of intestinal development and oncogenesis and its expression is highly specific to the intestinal epithelium. Colon cancers without CDX2 expression are often associated with an increased likelihood of aggressive features such as advanced stage, poor differentiation, vascular invasion, BRAF mutation, and the CpG island methylator phenotype.
Keywords:
Colorectal Carcinoma; CDX2; immunohistochemistry
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