Sandeep Kumar
PhD Scholar DEPARTMENT OF LIFE SCIENCS MONAD UNIVERSITY, Hapur (UP)
Dr. Akhilesh Kumar
Assistant Professor Govt. PG College Narnaul (HR)
Download PDFTransfersome is a term registered as a trademark by the German company IDEA AG, used to refer to its proprietary drug delivery technology. The name means “carrying body”, and is derived from the Latin word 'transferre', meaning „to carry across‟, and the Greek word „soma‟, for a „body‟. A Transfersome carrier is an artificial vesicle designed to be like acell vesicle or a cell engaged in exocytosis, and thus suitable for controlled and, potentially targeted, drug delivery. The term Transfersome and the underlying concept were introduced in 1991 by Gregor Cevc. Numerous groups have since been working with similar carriers, frequently under different names (elastic vesicle, flexible vesicle, Ethosome, etc.) to describe them. In a broader sense, a Transfersome is a highly adaptable and stress-responsive, complex aggregate. Its preferred form is an ultradeformable vesicle possessing an aqueous core surrounded by the complex lipid bilayer. Interdependency of local composition and shape of the bilayer makes the vesicle both self-regulating and self-optimizing. This enables the Transfersome to cross various transport barriers efficiently, and then act as a Drug carrier for non-invasive targeted drug delivery and sustained release of therapeutic agents. The carrier aggregate is composed of at least one amphiphat (such as phosphatudylcholine), which in aqueous solvents self-assenbles into lipid bilayer that closes nto a simple lipid vesicle. Bby addition of at least one bilayer softening component (such as a biocompatible surfactant or an amphiphile drug) lipid bilayer flexibility and permeability are greatly increased. The resulting, flexibility and permeability optimised, Transfersome vesicle can therefore adapt its shape to ambient easily and rapidly, by adjusting local concentration of each bilayer component to the local stress experienced by the bilayer. In its basic organization broadly similar to a liposome), the Transfersome thus differs from such more conventional vesicle primarily by its "softer", more deformable, and better adjustable artificial membrane.
Keywords: component ; flexibility and permeability ;conventional
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