This paper presents a review summary of the Pharmacological effects of Metalloporphyrins in Hypobaric hypoxia stress condition. The hypobaric hypoxia conditions leads to significant oxidative stress in humans. We proposed to study the effects of hypobaric hypoxia on hemeoxygenase level and also to correlate the role of Metalloporphyrins in modulating hemeoxygenase expression and the physiologic significance of hemeoxygenase induction and suppression in oxidative stress induced by hypobaric hypoxia. The Metalloporphyrins are a class of drug known for modulating the hemeoxygenase activity. Different Metalloporphyrins may cause various response at different levels of cellular activity.

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