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Toxicity in Molecules: Analysing the Key Parameters in Determining the Poison Levels to Develop an Analysis Metrics

Gatik Gola

Student, King’s College, Taunton, UK

1-7

Vol: 8, Issue: 3, 2018

Receiving Date: 2018-04-20 Acceptance Date:

2018-06-29

Publication Date:

2018-07-08

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Abstract

The study of toxicity in a molecule has become a common theme of research nowadays. Molecules are said to be poisonous if they interfere with the body’s chemistry and alter it in such a way that leads to a rather unconventional mode of the human biological mechanism. Therefore, a poison can be defined in several ways and the three most important things which determine whether a chemical can be described as poison are (1) its effect on the human body, (2) its speed of action in the body, (3) the effect it has in small doses. It is not specifically true for poison to show severe negative effects in high doses.Some poisons are really strong and effective so less of it is required to cause death. Whereas for weak poisons, you need more of it to kill someone. Therefore, the potency of poison decides what effects it will show and how quickly the symptoms will unfold. Poisons have different structures and functions and they exhibit distinct properties when they come into contact with human cells. Some poisons aim for the digestive system, some for the nervous system, and this all varies with the affinity of the poison molecule with a specific section of our body. In short, some poisons exploit the sensitivity of receptors on the target cells and affect the components of the cells required to complete processes essential for human life. Therefore, I have chosen three poisons to explain my ideas in detail, all of which result in different symptoms due to a meeting of poisonous molecular structures with the delicate receptor molecules.

Keywords: Doses; Effect; Toxicity; Protein; Blockage; Mechanism; Receptors; Structures

References

  1. https://www.khanacademy.org/science/biology/cellular-respiration-and-fermentation/oxidative-phosphorylation/v/oxidative-phosphorylation-and-the-electon-transport-chain
  2. “Molecules of Murder” chapter 8 ‘Cyanide and the Death on the Nile’, 8.2- The Chemistry of Cyanide Pg-156-157
  3. “A Level Biology for OCR” Chapter 18.4- Oxidative phosphorylation.
  4. “Molecules of Murder”, John Emsley,Royal Society of Chemistry (23 Jun. 2017)
  5. Walsh MJ, Dodd JE, Hautbergue GM. Ribosome-inactivating proteins: Potent poisons and molecular tools. Virulence. 2013;4(8):774-784. doi:10.4161/viru.26399. (Introduction) • http://pdb101.rcsb.org/motm/161
  6. ISBN 978-1-78262-474-5 “Molecules of Murder” chapter 1 ‘Ricin and the rolled Umbrella’, 1.2- Toxicology and Chemistry Pg-4
  7. https:/calpoison.org/news/strychnine-poisoning
  8. ISBN 978-0125506403 ‘Handbook of Membrane channels: Molecular and Cellular Physiology by Robert Vandenberg and Peter Schofield’ Chapter 21- Inhibitory Glycine and GABAA receptors Pg. 327-328.
  9. https://en.wikipedia.org/wiki/Strychnine, ‘Mechanism of action’
  10. https://en.wikipedia.org/wiki/Strychnine, ‘Mechanism of action’
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